FREQUENTLY ASKED QUESTIONS

When it comes to any treatment, you should always ask questions. And we're here to help.

FREQUENTLY ASKED QUESTIONS

When it comes to any treatment, you should
always ask questions. And we're here to help.

What is going on in my body during menopause?

HOW COMMON ARE VAGINAL SYMPTOMS AFTER MENOPAUSE?

At least 1 in 2 of postmenopausal women experience vulvar and vaginal atrophy, and painful sex is a common symptom. While it’s not usually discussed as openly as hot flashes and night sweats, you’re certainly not the only one. To learn more, click here.

HOW CAN I TELL IF IT’S VULVAR AND VAGINAL ATROPHY?

With vulvar and vaginal atrophy (VVA), you may experience dryness, burning, and itching in and around the vagina. And having sex may be painful. If you’re experiencing any of these symptoms, make an appointment to see your healthcare provider. There are prescription treatments that may be able to help. IMVEXXY can help with moderate to severe painful sex after menopause. To prepare for your appointment, fill out a personalized guide here.

CAN I JUST USE ONE OF THOSE PERSONAL LUBRICANTS?

Over-the-counter lubricants may give you some temporary relief from your mild symptoms. But they don’t actually address the root of the problem and treat the real underlying condition. To learn more, click here.

What is IMVEXXY?

WHAT DOES IMVEXXY DO?

IMVEXXY is used after menopause to treat moderate to severe painful sex, a symptom of changes in and around your vagina, due to menopause. To learn more, click here.

WHEN WILL I START TO FEEL A DIFFERENCE WITH PAINFUL SEX ON IMVEXXY?

In as fast as just 2 weeks, IMVEXXY starts treating the actual reason for painful sex after menopause: vulvar and vaginal atrophy (VVA) caused by estrogen loss. In fact, in a 12-week clinical study, most menopausal women who used IMVEXXY experienced relief from painful sex. To learn more, click here.

IS IMVEXXY A LOCAL HORMONE REPLACEMENT THERAPY?

Yes. It’s the only softgel vaginal insert (not a pill) that has bio-identical, locally administered estrogen that mimics the estrogen your body makes naturally.* There are some risks with hormone replacement therapy that you can read about here.

*Bio-identical hormones are hormones that are structurally identical to the hormones your body produces naturally. It is not known if there is a difference in risks between synthetic hormones and bio-identical hormones.

What do I need to know before using IMVEXXY?

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT IMVEXXY (AN ESTROGEN HORMONE)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone or with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone or with progestin may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone or with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • Talk to your doctor regularly about whether you still need treatment with IMVEXXY.

HOW DO I TALK TO MY HEALTHCARE PROVIDER ABOUT PAINFUL SEX AND VULVAR AND VAGINAL ATROPHY?

We know that for a lot of women, it can be difficult or even embarrassing to talk about this. We’re here to help. Check out our doctor discussion guide here or click here for more guidance.

WHAT ARE THE MOST COMMON SIDE EFFECTS OF IMVEXXY?

The most common side effects are headache, breast tenderness or pain, and nausea and vomiting. Learn more about any potential side effect here.

HOW SHOULD I USE IMVEXXY?

For detailed instructions on how to insert IMVEXXY, click here or see a detailed step-by-step PDF here.

How do I get IMVEXXY?

HOW CAN I GET IMVEXXY?

You don’t have to wait until your annual check-up to ask about painful sex and IMVEXXY. Speak to a healthcare provider now to see if IMVEXXY is right for you and learn how you can get a prescription. Click here to learn more.

HOW MUCH WILL MY PRESCRIPTION COST?

Taking care of your vagina shouldn’t mean you can’t take care of your wallet, too. Some prescriptions can get pricey, but nothing should stand in the way of your health. Find out how you can get IMVEXXY for as little as $35* with our savings card here.

*Savings card offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, and Eligibility Criteria here

Important Risk Information

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER

See full prescribing information for complete boxed warning.


Estrogen-Alone Therapy

  • There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens
  • The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT)
  • The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
  • Do not use estrogen-alone therapy for the prevention of cardiovascular disease or dementia

Estrogen Plus Progestin Therapy

  • The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE) and myocardial infarction (MI)
  • The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer
  • The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
  • Do not use estrogen plus progestogen therapy for the prevention of cardiovascular disease or dementia

The WHI estrogen-alone and estrogen plus progestin substudies evaluated only daily oral conjugated estrogens (CE) [0.625 mg] and medroxyprogesterone acetate (MPA) [2.5 mg]. Therefore, the relevance of the WHI findings regarding adverse cardiovascular events, dementia, and breast cancer to lower CE and MPA doses, other routes of administration, or other estrogen-alone or estrogen plus progestogen products is not known, and cannot be definitively excluded or determined.

MOST IMPORTANT INFORMATION YOU SHOULD KNOW ABOUT IMVEXXY(an estrogen hormone)

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age and older.
  • Do not use estrogens with progestogens to prevent heart disease, heart attacks, strokes or dementia.
  • Using estrogens with progestogens may increase your chance of getting dementia, based on a study of women 65 years of age and older.
  • Only one estrogen-alone product and dose have been shown to increase your chances of getting strokes, blood clots, and dementia. Only one estrogen with progestogen product and dose have been shown to increase your chances of getting heart attacks, strokes, breast cancer, blood clots, and dementia. Because other products and doses have not been studied in the same way, it is not known how the use of IMVEXXY will affect your chances of having these conditions.
  • Talk to your healthcare provider regularly about whether you still need treatment with IMVEXXY.

Do not use if you

  • have unusual vaginal bleeding.
  • have been diagnosed with a bleeding disorder.
  • currently have or have had certain cancers.
  • currently have or have had blood clots.
  • had a stroke or heart attack.
  • currently have or have had liver problems.
  • are allergic to IMVEXXY or any of its ingredients.

Warnings

Tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual vaginal bleeding.
  • have any other medical conditions that may become worse while you are using IMVEXXY.
  • have asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
  • are going to have surgery or will be on bed rest. You may need to stop using IMVEXXY.
  • are pregnant or think you may be pregnant. Imvexxy is not for pregnant women.
  • are breast feeding.

Tell your healthcare provider about all the medicines you take.

IMVEXXY may affect the way other medicines work, and other medicines may affect how IMVEXXY works.

When using IMVEXXY you may have

  • headache
  • breast tenderness or pain
  • nausea and vomiting

USE

IMVEXXY (estradiol vaginal inserts) is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.



The risk information provided here is not complete. To learn more, talk about IMVEXXY with your healthcare provider or pharmacist. The FDA-approved product labeling can be found here.



You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch, or call 1-800-FDA-1088.

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