When you think of menopause, which symptoms come to mind? Hot flashes and sweating day and night? These symptoms are common, but many menopausal women also experience vaginal pain, especially during sex.

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Estrogen loss may be the source of your pain

Less Estrogen

With menopause, the amount of estrogen in a woman’s body decreases.

Changes to the Vagina

Lower estrogen levels can cause changes to the vagina, including changes in vaginal pH and thinning of vaginal tissues.


These changes can cause vaginal pain and discomfort.

Vaginal pain associated with sexual activity
may be a symptom of a medical condition

Painful sex due to menopause, also referred to as dyspareunia (pronounced dis-pa-roo-nee-ya), is a common symptom of a condition called vulvar and vaginal atrophy, or VVA. If you haven’t heard of vulvar and vaginal atrophy or dyspareunia before, don’t worry. For many people, these aren’t familiar terms. Women may describe it as “vaginal discomfort and pain” when describing their symptoms.

Other symptoms and conditions associated with VVA may include:

  • Vaginal Dryness
  • Vaginal and/or vulvar irritation/itching
  • Dysuria (difficulty with urination)
  • Vaginal bleeding

IMVEXXY is NOT indicated for the treatment of these other VVA symptoms.

If you feel vaginal pain, you are not alone

1 in 2 menopausal women experience symptoms of VVA, which can include pain during sexual activity. Despite suffering with pain, many women do not seek help, or they wait a long time before seeing a healthcare provider about the problem.

Why don’t women discuss topics like painful sex or vaginal health with their healthcare provider? According to studies, the main reasons are:

  • Too embarrassed
    to discuss

  • Think it can’t
    be treated

  • Feel it’s too

  • Trying to manage with

Don’t keep the pain to yourself. Treatments like IMVEXXY can provide relief of moderate to severe vaginal pain due to sexual activity. Talk to your healthcare provider about your options today.

Talking about vaginal discomfort
and pain isn't easy

Vaginal pain affects sex and can put a lot of stress on a woman. If you’re experiencing symptoms of painful sex during menopause, don’t suffer. Learn about your treatment options and make finding relief a priority.

Talk to a Provider

To find relief you have to start
the discussion

Download our simple discussion guide that offers tips for bringing up the topic of painful sex due to menopause as well as making the most of your time with your healthcare provider.

Discover IMVEXXY
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IMVEXXY® is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Important Risk Information


  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone or with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone or with progestin may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone or with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • Talk to your doctor regularly about whether you still need treatment with IMVEXXY.

Do not use if you

  • have unusual vaginal bleeding.
  • currently have or have had certain cancers.
  • currently have or have had blood clots.
  • had a stroke or heart attack.
  • currently have or have had liver problems.
  • have been diagnosed with a bleeding disorder.
  • are allergic to IMVEXXY or any of its ingredients.
  • think you may be pregnant.


Tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual vaginal bleeding.
  • have asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
  • are going to have surgery or will be on bed rest. You may need to stop using IMVEXXY.
  • are breast feeding.

Tell your healthcare provider about all the medicines you take. IMVEXXY may affect the way other medicines work, and other medicines may affect how IMVEXXY works.

When using IMVEXXY you may have

  • headache
  • breast tenderness or pain
  • nausea and vomiting

The risk information provided here is not complete. To learn more, talk about IMVEXXY with your healthcare provider or pharmacist. The FDA-approved product labeling can be found here.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch, or call 1-800-FDA-1088. You may also report side effects to TherapeuticsMD at 1-888-228-0150

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