As you lose estrogen during menopause, your body changes, which can result in vaginal discomfort, and make many activities painful, especially sex. IMVEXXY was designed to relieve moderate to severe vaginal pain associated with sexual activity.

Replenish your estrogen. and feel comfortable about it.

What you put into your body matters. You have options, so consider a bio-identical estrogen that comes in an ultra-low dose.

IMVEXXY is a bio-identical* estrogen therapy

Bio-Idential Icon

A scientific term that means it was made to match your body’s own estrogen.

IMVEXXY is the only ultra-low-dose estrogen therapy

Ultra Low Dose Icon

Professional guidelines recommend using the lowest dose of estrogen that offers therapeutic benefits.

Find out if IMVEXXY is right for you.

Talk to a Provider

*IMVEXXY is bio-identical estradiol that is structurally identical to the estrogen produced in the body. The relevence of risks associated with the use of synthetic hormones compared to bio-identical hormones is not known but cannot be excluded.

Relieve vaginal pain associated with sexual activity,
a symptom of vva, by restoring vaginal health

In a study, menopausal women who took IMVEXXY for 12 weeks experienced relief from painful sex. Some women began to experience relief as early as 2 weeks after beginning treatment.

IMVEXXY provides relief by restoring pH levels and improving vaginal tissues to support vaginal health.

While IMVEXXY was studied over the course of 12 weeks, your healthcare provider may recommend that you continue with treatment to maintain vaginal health for relief from painful sex. IMVEXXY should be taken at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.

Copy Icon

For more details on the results you can expect with IMVEXXY, see Patient Information.

How to use IMVEXXY

To Start

Place a single IMVEXXY softgel vaginal insert once daily, at about the same time, for the first 2 weeks. IMVEXXY is only for use in the vagina. Do not take IMVEXXY by mouth (orally).

IMVEXXY Starter Pack Photo
  • 1 INSERT
  • 1x DAILY
  • 2 WEEKS

To Maintain

Place a single IMVEXXY softgel vaginal insert twice weekly, every 3 to 4 days (for example, Monday and Thursday), for as long as you use IMVEXXY.

IMVEXXY Maintenance Pack Photo
  • 1 INSERT
  • 2x WEEKLY
Copy Icon

For more details on dosing see IMVEXXY Patient Information.

Easy to insert. Easy to live with.

In a patient survey, 88% of women said IMVEXXY is easy to use and 80% found it easy to insert.*

  • Easy To Use

  • Insert Any Time
    of Day

  • No Downtime
    After Use

  • Avoid

*A patient survey evaluated the acceptability of the product administration experience and was completed at the end of the study by women in 4-mcg, 10-mcg, and matching softgel placebo arms (N=574).

How to insert IMVEXXY

  • STEP 1: HOLD

    Push one IMVEXXY insert through the foil of the blister pack and hold the IMVEXXY insert with the larger end between your fingers. Remember to wash and dry your hands before handling IMVEXXY.


    You can insert IMVEXXY lying down or standing. Select the position that is most comfortable for you, and then with the smaller end facing up, use your finger to place the insert about two inches into your vagina.


    Once IMVEXXY is inserted, there’s no downtime.

    TO USE

    For a visual guide and detailed instructions about placing IMVEXXY in your vagina, see the Instructions for Use.



IMVEXXY® is a prescription medicine that contains an estrogen hormone in a vaginal insert. It is used after menopause to treat moderate to severe painful intercourse, a symptom of changes in and around your vagina, due to menopause.

Important Risk Information


  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb).
  • Report any unusual vaginal bleeding right away while you are using IMVEXXY. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone or with progestins to prevent heart disease, heart attacks, strokes, or dementia (decline of brain function).
  • Using estrogen-alone or with progestin may increase your chances of getting strokes or blood clots.
  • Using estrogen-alone or with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Using estrogens with progestins may increase your chances of getting heart attacks or breast cancer.
  • Talk to your doctor regularly about whether you still need treatment with IMVEXXY.

Do not use if you

  • have unusual vaginal bleeding.
  • currently have or have had certain cancers.
  • currently have or have had blood clots.
  • had a stroke or heart attack.
  • currently have or have had liver problems.
  • have been diagnosed with a bleeding disorder.
  • are allergic to IMVEXXY or any of its ingredients.
  • think you may be pregnant.


Tell your healthcare provider about all of your medical conditions, including if you:

  • have any unusual vaginal bleeding.
  • have asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, angioedema (swelling of face and tongue), problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
  • are going to have surgery or will be on bed rest. You may need to stop using IMVEXXY.
  • are breast feeding.

Tell your healthcare provider about all the medicines you take. IMVEXXY may affect the way other medicines work, and other medicines may affect how IMVEXXY works.

When using IMVEXXY you may have

  • headache
  • breast tenderness or pain
  • nausea and vomiting

The risk information provided here is not complete. To learn more, talk about IMVEXXY with your healthcare provider or pharmacist. The FDA-approved product labeling can be found here.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch, or call 1-800-FDA-1088. You may also report side effects to TherapeuticsMD at 1-888-228-0150

Talk To A Provider Icon